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The Renal Structural and Functional Changes ID in Rats with Intrauterine Growth Retardation and its Correlation to Serum Leptin Level [J Child]
J Child. 2019; 19(1): 27-36 | DOI: 10.5222/j.child.2019.92259  

The Renal Structural and Functional Changes ID in Rats with Intrauterine Growth Retardation and its Correlation to Serum Leptin Level

Sebahat Tülpar1, Zübeyde Gündüz1, Nurcan Dursun2, Figen Öztürk3, Nedret Koç4
1Department of Pediatric Nephrology, Erciyes Medical University, Kayseri
2Department of Physiology, Erciyes Medical University
3Department of Pathology, Erciyes Medical University, Kayseri
4Department of Microbiology, Erciyes Medical University, Kayseri

INTRODUCTION: Our aim was to determine the effects of intrauterine growth retardation (IUGR) on the kidney and whether serum leptin level was associated with these changes.
METHODS: After feeding with standard diet for 7 days pregnant rats divided into 2 groups in the 8th day. While the control group continued to feed with normal diet during pregnancy, the study group fed with only half of normal needs. Evaluations were performed in fetuses at day 21 and 3, 6, 16 weeks of age in offsprings. The kidney was investigated according to weight, light microscopy
findings, nephron number and glomerular volume as structural. Renal excretory function was determined for functional evaluation. Fetuses and 3 weeks old rat kidneys were investigated only structurally. Serum leptin levels were measured at 3, 6,16 weeks of age, direct blood pressure and renal blood flow were measured at 16 week of age.
RESULTS: Renal weights were lower in the IUGR groups. In IUGR group, nephron number was found to be lower in fetuses and 16-week-old. Urine flow rate, renal blood flow, GFR, excretions Na, K and, Mg were lower in the 16-week group compared to control but protein excretion was higher and blood pressure was normal. The IUGR rats had significantly elevated serum leptin levels at 3-week-old. The leptin levels in 6-week-old females were higher than controls by almost 60 %. For all ages there was a negative correlation between with leptin levels and fractional kidney weight. Leptin level and urine volume were correlated in the 6-week-old rats. There were positive correlations between leptin and blood pressure, excretions creatinin, Na and K at 16-week-old rats.
DISCUSSION AND CONCLUSION: In conclusion, temporary increase of serum leptin concentration during weaning may not be associated with the deleterious effect of kidney structure and function at least until early adulthood in IUGR.

Keywords: IUGR, kidney, leptin


İntrauterin Büyüme Gerilikli Ratlarda Böbrekte Yapısal/Fonksiyonel Değişiklikler ve Serum Leptin Seviyesiyle İlişkisi

Sebahat Tülpar1, Zübeyde Gündüz1, Nurcan Dursun2, Figen Öztürk3, Nedret Koç4
1Çocuk Nefroloji Departmanı, Erciyes Üniversitesi Tıp Fakültesi, Kayseri
2Fizyoloji Departmanı, Erciyes Üniversitesi Tıp Fakültesi, Kayseri
3Patoloji Departmanı, Erciyes Üniversitesi Tıp Fakültesi, Kayseri
4Mikrobiyoloji Departmanı, Erciyes Üniversitesi Tıp Fakültesi, Kayseri

GİRİŞ ve AMAÇ: Metinin tamamı İngilizce
YÖNTEM ve GEREÇLER: Metinin tamamı İngilizce
BULGULAR: Metinin tamamı İngilizce
TARTIŞMA ve SONUÇ: Metinin tamamı İngilizce

Anahtar Kelimeler: IUBG, böbrek, leptin


Sebahat Tülpar, Zübeyde Gündüz, Nurcan Dursun, Figen Öztürk, Nedret Koç. The Renal Structural and Functional Changes ID in Rats with Intrauterine Growth Retardation and its Correlation to Serum Leptin Level. J Child. 2019; 19(1): 27-36

Corresponding Author: Sebahat Tülpar, Türkiye


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