ISSN 1302-9940

Hzl Arama




The Journal of the Child nc basamak bir pediatrik endokrinoloji merkezinde izlenen ar boy ksal olgularnn etiyolojik deerlendirmesi [J Child]
J Child. 2019; 19(2): 63-76 | DOI: 10.5222/j.child.2019.18942

nc basamak bir pediatrik endokrinoloji merkezinde izlenen ar boy ksal olgularnn etiyolojik deerlendirmesi

Utkucan Ukun1, Firdevs Bas2, Sukran Poyrazoglu2, Mine kr2, Feyza Darendeliler2, Ruveyde Bundak3
1stanbul niversitesi stanbul Tp Fakltesi, ocuk Sal Ve Hastalklar Ana Bilim Dal, stanbul, Trkiye
2stanbul niversitesi stanbul Tp Fakltesi, Pediatrik Endokrinoloji Ana Bilim Dal, stanbul, Trkiye
3Girne niversitesi Tp Fakltesi, Pediatrik Endokrinoloji Ana Bilim Dal, Girne, Kuzey Kbrs Trk Cumhuriyeti

GR ve AMA: Aratrmamzn amac stanbul'da nc basamak bir Pediatrik Endokrinoloji merkezinde izlenen ar boy ksal olgularnn etiyolojik profilini ve karakteristiklerini incelemektir.
YNTEM ve GERELER: Rastgele seilen 500 ar boy ksal (boy SDS <-3SD) olgusundan izlem sresi 12 ay ve zeri olan 320 hasta almaya alnmtr
BULGULAR: Olgularn %94.1'inde patolojik boy ksal saptanmtr. Patolojik boy ksalklarnda en sk etiyolojik neden endokrin bozukluklar (%50,9) olarak saptanmtr. Bunu srasyla spesifik sendromlar ve kromozom anomalileri (%13,2), orantsz boy ksalklar (%12,8), kronik hastalklar ve malntrisyon (%12,8), catch-up bymeyi yakalayamayan gebelik yana gre kk (SGA) olgular (%3,8) ve psikososyal boy ksal (%0,6) izlemektedir. Endokrin bozukluklar iinde en sk etiyolojik neden byme hormonu eksikliidir. (%95,2)
TARTIMA ve SONU: Ar boy ksal olan ocuklarda patolojik boy ksal nedenleri dlanmaldr. Aratrmamz ar boy ksal olgularnda en sk etiyolojik nedenin endokrin bozukluklar olduunu gstermitir. Gerek tm olgularda gerek de endokrin bozukluklar iinde en sk etiyolojik neden byme hormonu eksiklii olarak saptanmtr.

Anahtar Kelimeler: ar boy ksal, ocuk, etiyoloji, byme hormonu eksiklii

Evaluation of the etiology of severe short stature in children at a tertiary pediatric endocrinology centre

Utkucan Ukun1, Firdevs Bas2, Sukran Poyrazoglu2, Mine kr2, Feyza Darendeliler2, Ruveyde Bundak3
1Istanbul University Istanbul Faculty of Medicine, Department of Pediatrics, Istanbul, Turkey
2Istanbul University Istanbul Faculty of Medicine, Department of Pediatric Endocrinology, Istanbul, Turkey
3University Of Kyrenia Faculty Of Medicine, Department Of Pediatric Endocrinology, Kyrenia, Turkish Republic Of North Cyprus

INTRODUCTION: The aim of this study was to describe the characteristics and the etiological profile of children with severe short stature evaluated at a tertiary Pediatric Endocrinology centre in Istanbul
METHODS: Randomly selected 500 patients with the diagnosis of severe short stature (height SDS<-3SD) were selected for this study. Among those, 320 patients with at least 12 months of follow-up were included
RESULTS: Among these patients pathological short stature was diagnosed in 94.1%. Endocrine disorders (50.9%) was found to be the leading cause among pathological short stature; followed by specific syndromes and chromosomal abnormalities (13.2%), disproportionate short stature (12.8%), chronic diseases and malnutrition (12.8%), small for gestational age (SGA) with failure of catch-up growth (3.8%) and psychosocial short stature (0.6%). Of those with endocrine disorders; the most common etiology was growth hormone deficiency (GHD) (95.2%)
DISCUSSION AND CONCLUSION: Pathological causes should be ruled out in children with severe short stature. Our results showed that the most common cause was GHD among all subjects.

Keywords: severe short stature, children, etiology, growth hormone deficincy

Utkucan Ukun, Firdevs Bas, Sukran Poyrazoglu, Mine kr, Feyza Darendeliler, Ruveyde Bundak. Evaluation of the etiology of severe short stature in children at a tertiary pediatric endocrinology centre. J Child. 2019; 19(2): 63-76

Sorumlu Yazar: Utkucan Ukun, Trkiye
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