ISSN 1302-9940 | e-ISSN 1308-8491

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The Journal of the Child Akut Ebstein-Barr Virs Enfeksiyonu Srasnda Saptanan Hiperamilazemi [J Child]
J Child. 2019; 19(2): 96-99 | DOI: 10.5222/j.child.2019.50470

Akut Ebstein-Barr Virs Enfeksiyonu Srasnda Saptanan Hiperamilazemi

Ferhan Ta1, mer Suat Fitz2, Ergin ifti3
1Ankara niversitesi Tp Fakltesi, ocuk Sal Ve Hastalklar Ana Bilim Dal, Ankara
2Ankara niversitesi Tp Fakltesi, ocuk Radyolojisi Bilim Dal, Ankara
3Ankara niversitesi Tp Fakltesi, ocuk Enfeksiyon Hastalklar Bilim Dal, Ankara

Makroenzimler, fizyolojik ya da patolojik durumlarda serumda bulunan yksek molekler arlkl enzimlerdir. Makroamilaz, ilk tanmlanm olan ve en sk grlen makroenzimdir. Burada makroamilazemi bir ocuk hasta sunulmutur. yanda erkek hasta ate ve boyunda ilik nedeniyle getirildi. Muayenesinde servikalde ok sayda lenfadenopatisi, hepatomegali ve splenomegali saptand. Atei, servikal lenfadenopati, hepatomegali, splenomegalisi olan ve periferik yaymasnda atipik lenfositleri saptanan hastada akut Ebstein-Barr virs enfeksiyonu dnld. Laboratuar tetkiklerinde amilaz dzeyi yksek saptand ve EBV enfeksiyonuna sekonder parotit gibi bir komplikasyon olabilecei dnld. Tedavisiz izlenen hastann takiplerinde ikayetleri ve muayene bulgular gerilemesine ramen amilaz dzeyinin yksek seyrettii grld. Amilaz ykseklii nedeniyle yaplan tkrk bezi ultrasonografisinde (USG) viral enfeksiyona sekonder olabilecek bulgular olduu grld. Yaplan abdominal USGde pankreas normal ve minimal splenomegali saptand. Baklan fraksiyone amilaz klirensi <%1 saptanan hastada amilaz yksekliinin geirilen enfeksiyon ile ilikili olmaktan ok makroamilazemiye bal olduu kansna varld. Amilaz ykseklii tesadfen bulunmu bir laboratuar bozukluk olarak karmza kabilir. Makroamilazeminin tannmas hastalara gereksiz inceleme ve giriim yaplmasn nleyebilir.

Anahtar Kelimeler: Amilaz, makroamilazemi, makroenzim, Ebstein-Barr virs

Hyperamilasemia Determined in the Course of Ebstein-Barr Virus Infection

Ferhan Ta1, mer Suat Fitz2, Ergin ifti3
1Department Of Pediatrics, Ankara University Faculty Of Medicine, Ankara, Turkey
2Department Of Pediatric Radiology, Ankara University Faculty Of Medicine, Ankara, Turkey
3Division Of Pediatric Infectious Diseases, Ankara University Faculty Of Medicine, Ankara, Turkey

Macroenzymes are the high molecular weight enzymes which could be in the serum in physiologic or pathologic situations. The first described macroenzyme is macroamylase and it is seen most frequently as macroenzyme. Here we present a child with macroamylasemia. A 3-year-old boy admitted to the hospital with fever and cervical swelling. On the examination, there were several cervical lymphadenopathies, hepatomegaly and splenomegaly. Patient had been thought to have acute Ebstein-Barr virus (EBV) infection because of having fever, cervical lymphadenopathies, hepatomegaly, splenomegaly and atypical lymphocytes on the peripheral smear also. On laboratory findings, amylase levels were elevated. It was thought to be a secondary complication, like parotitis, due to EBV infection. After following patient without any treatments, complaints and all findings are regressed except amylase levels. Salivary gland and abdominal ultrasonography (USG) were performed to find the cause of elevated amylase levels. On the salivary gland USG, there were findings secondary to viral infections and on the abdominal USG, pancreas was normal but there was minimal splenomegaly. Fractional excretion of amylase level is determined <%1 on the patient. After all findings, as a conclusion, elevated amylase levels on our patient is thought to result from macroamylasemia rather than EBV infection. High amylase level could be determined incidentally. Recognizing macroamylasemia could prevent unnecessary examinations and interventions to patients.

Keywords: Amylase, macroamylasemia, macroenzym, Ebstein-Barr virus

Ferhan Ta, mer Suat Fitz, Ergin ifti. Hyperamilasemia Determined in the Course of Ebstein-Barr Virus Infection. J Child. 2019; 19(2): 96-99

Sorumlu Yazar: Ferhan Ta, Trkiye
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